A cutoff value of 321 white blood cell/μL showed the best combination of sensitivity (80.6%) and specificity (81.4%) for the diagnosis of bacterial meningitis (area under receiver operating characteristic curve 0.837). cerebrospinal fluid white blood cell count was significantly higher in patients with bacterial meningitis (mean, 4839 cells/μL) compared to patients with aseptic meningitis (mean, 159 cells/μL, p < 0.001), with those with aseptic meningitis (mean, 577 cells/μL, p < 0.001) and with all non-bacterial meningitis cases together ( p < 0.001). Bacterial meningitis was caused by Neisseria meningitidis (48.4%), Streptococcus pneumoniae (32.3%), other Streptococcus species (9.7%), and other agents (9.7%). Thirty one children (10.5%) were diagnosed with bacterial meningitis, 156 (52.9%) viral meningitis and 108 (36.6%) aseptic meningitis. There were 295 patients with cerebrospinal fluid pleocytosis, 60.3% females, medium age 5.0 ± 4.3 years distributed as: 12.2% 1–3 months 10.5% 3–12 months 29.8% 12 months to 5 years 47.5% >5 years. The cases of traumatic lumbar puncture and of antibiotic treatment before lumbar puncture were excluded. A retrospective study of children aged 29 days to 17 years who were admitted between January 1st and December 31th, 2009, with cerebrospinal fluid pleocytosis (white blood cell ≥ 7 μL −1) was conducted. Our aim was to establish a cutoff point of cerebrospinal fluid white blood cell count that could distinguish bacterial from viral and aseptic meningitis. Although some clinical prediction rules, such as bacterial meningitis score, are of well-known value, the cerebrospinal fluid white blood cells count can be the initial available information. read more (such as people with HIV infection) may have shingles more than once.Children with cerebrospinal fluid pleocytosis are frequently treated with parenteral antibiotics, but only a few have bacterial meningitis. However, people with a weakened immune system Overview of Immunodeficiency Disorders Immunodeficiency disorders involve malfunction of the immune system, resulting in infections that develop and recur more frequently, are more severe, and last longer than usual. Unlike HSV infections, which can recur many times, shingles usually occurs only once in a person's lifetime. read more (herpes zoster) and may cause meningitis. When it reactivates, it causes shingles Shingles Shingles is a painful skin rash caused by a viral infection that results from reactivation of the varicella-zoster virus, the virus that causes chickenpox. The virus may never cause symptoms again, or it may reactivate many years later. Like HSV-2, the varicella-zoster virus remains in the body in a nonactive state. The varicella-zoster virus causes chickenpox Chickenpox Chickenpox is a highly contagious viral infection with the varicella-zoster virus that causes a characteristic itchy rash, consisting of small, raised, blistered, or crusted spots. Meningitis is inflammation of the layers of tissue that cover the brain and spinal cord (meninges) and of the fluid-filled space. Thus, meningitis due to HSV-2 Viruses Recurrent meningitis is meningitis that occurs more than once. However, it can become active again (reactivate) periodically and cause symptoms. After symptoms disappear, HSV-2 remains in the body in a nonactive (dormant) state. Symptoms of meningitis may appear before the genital symptoms, and some people have meningitis but do not have any genital symptoms. Genital and meningitis symptoms can occur at the same time. HSV-2 meningitis usually occurs when the virus first infects the body. HSV-2 can also cause symptoms of meningitis. read more, a sexually transmitted infection that causes painful blisters in the genital area. HSV-2 causes genital herpes Herpes Simplex Virus (HSV) Infections Herpes simplex virus infection causes recurring episodes of small, painful, fluid-filled blisters on the skin, mouth, lips (cold sores), eyes, or genitals.
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